ISSN 2490-3329 (Print)
ISSN 2303-7954 (Online)

Volume 47, Issue 2, Article 9

(Scr Med 2016:47:140-147)

Drug Induced Liver Injury: Pathogenesis, Clinical Features and Monitoring

Ana Ćurguz,1 Lana Nežić,2 Danijela Mandić3

1 Division of Pharmacy, School of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina
2 Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina
3 Clinic of Internal Medicine, University Clinical Center of the Republic of Srpska, 78000 Banja Luka, Bosnia and Herzegovina

UDK 616.36-002:615.2
COBISS.RS-ID 6165016


Introduction: Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reactions. DILI may mimic pathophysiology or histopathologic features of an acute or chronic liver disease, and they may be indistinguishable from those of other causes of liver injuries. Liver can be affected directly, in a dose-dependent manner, or idiosyncratically, independently of the dose, and therefore unpredictably developed.

Methods: In this special article we provided results given in the articles published in PubMed in the period 2006-2016. The search was made based on the most frequent reported drugs inducing liver injuries, diagnostic assessment, monitoring and outcomes of DILI.

Results: The true incidence of DILI still remains unknown but the incidence of up to 14 cases per 100,000 inhabitants/year has been most frequently reported. Antimicrobial agents, analgesics, hipolipemics and antiepileptics are the most common drugs causing DILI.

Conclusion: Although several biomarkers have been found through analytical tests, none of them have been able to display enough specificity and sensitivity in DILI diagnosis. Therefore, diagnostic assessment of DILI is still based on clinical examination, pharmacological treatment history, current RUCAM criteria, and liver function laboratory test.

Key words: drugs, hepatotoxicity, idiosyncrasies, pharmacogenetics, RUCAM criteria


PDF version of article

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Contact address:
Lana Nežić,
14 Save Mrkalja St,
78000 Banja Luka, Bosnia and Herzegovina
Phone: 00387 (0)51 234 100
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Submitted: September 13th, 2016       
Accepted: September 21st, 2016