ISSN 2490-3329 (Print)
ISSN 2303-7954 (Online)

Volume 50, Issue 2, Article 3

Verhaz et al. Scr Med 2019;50(2):77-81.

ORIGINAL ARTICLE

Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir ± Dasabuvir± Ribavirin in Treatment of Patients With Chronic Hepatitis C in the Republic of Srpska: a Real-Life Study

Antonija Verhaz1,2, Zdravka Kezić1, Miloš P. Stojiljković3, Ranko Škrbić3

(1) Clinic for Infectious Diseases, University Clinical Centre of the Republic of Srpska, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina
(2) Department for Infectious Diseases, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina
(3) Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.

 

DOI 10.5937/scriptamed50-22255

UDK 616.36-002(497.6RS)
COBISS.RS-ID 8317208

 

ABSTRACT

Background: The purpose of this study was to assess the antiviral efficacy and safety of the direct-acting antivirals (DAAs) in therapy of chronic hepatitis C virus (HCV) infection.
Methods: This real-life multi-centric study was performed at the Clinic for Infectious Diseases, University Clinical Centre of the Republic of Srpska, Banja Luka and it included a total of 89 patients. All patients received the adequate doses of ombitasvir (OBV)/ paritaprevir (PTV)/ritonavir (RTV) + dasabuvir (DSV) plus ribavirin (RBV). RBV was given to all patients except to those with HCV sub-genotype 1b. DSV was not administered to patients infected with HCV genotype 4. For the majority of patients the treatment duration was 12 weeks. For ten patients with liver cirrhosis the duration of treatment was 24 weeks. Viraemia was assessed at three points in time: at baseline, 12 or 24 weeks after the beginning of treatment (end of treatment response - ETR), and 12 weeks after the end of treatment (sustained viral response - SVR).

Results: Complete ETR after 12 weeks of treatment was achieved in 79 patients, while in 10 high-risk patients it was achieved after 24 weeks of treatment. Full SVR was recorded in 88 patients 12 weeks after the end of treatment. This therapy was well tolerated and mild adverse effects were recorded in only 10 patients.

Conclusion: Treatment of patients with chronic HCV infection with OBV/PTV/RTV+ DSV + RBV resulted in excellent antiviral activity and mild adverse events.

Key words: hepatitis C virus, ombitasvir, paritaprevir, ritonavir, dasabuvir, ribavirin.

 

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