ISSN 2490-3329 (Print)
ISSN 2303-7954 (Online)

Volume 50, Issue 2, Article 2

Dabeski et al. Scr Med 2019;50(2):69-76.

ORIGINAL ARTICLE

Human Papillomavirus Infections in Women With and Without Squamous Cell Abnormalities of the Uterine Cervix

Drage Dabeski1, Ana Dabeski1, Vesna Antovska1, Milka Trajanova1, Irena Todorovska1, Aneta Sima1

(1) Department of Gynaecology, University Clinic for Gynaecology and Obstetrics, Skopje, the Republic of North Macedonia.

DOI 10.5937/scriptamed50-21910

UDK  616.98:578.827
COBISS.RS-ID 8316952

 

 

ABSTRACT

Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix.

Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation.

Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%.

Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.

Key words: human papillomavirus, squamous cell abnormalities, uterine cervix.

 

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