ISSN 2490-3329 (Print)
ISSN 2303-7954 (Online)

Volume 49, Issue 1, Article 4

(Scr Med 2018:49:25-29)
ORIGINAL ARTICLE

Status Epilepticus in Our Patients, 15-Years Follow-Up Study

Duško Račić1, Siniša Miljković1, Vlado Đajić1, Zoran Vujković1, Aleksandra Dominović1, Sanja Grgić1, Verica Dragović1

¹University Clinical Center of the Republic of Srpska, Clinic of Neurology, Banjaluka, Republic of Srpska, Bosnia and Herzegovina


doi: 10.18575/msrs.sm.e.18.04
UDC: 616.853-053.8
COBISS.RS-ID: 7317016


ABSTRACT

Introduction: Status epilepticus (SE) is the second most frequent neurological emergency. The purpose of this study was to analyse clinical presentation, causes and outcome of SE.

Aim of the Study: The was was to establish clinical characteristics, etiology and the outcome of  status epilepticus as well as sex and age distribution in patients hospitalized at the Clinic of Neurology UCC RS in a 15-year follow-up. 

Patients an Methods: In this prospective 15-year study, all patients with SE admitted to the  University Clinical Center of Republic of Srpska, Clinic of Neurology, were treated in the period of 15 years (2003-2017). Demographic and clinical data were collected.

Results: In the aforesaid period, 124 patients with SE were treated, and there were 71 man (57%) with mean age of 59 years and 54 woman (43%), with mean age of 52.5 years. Primarily generalized tonic-clonic SE was identified in 70 (56%) and 44 (35.2%) patients, retrospectively. Simple partial SE occurred in 10 (8%) patients. 62% of the patients had previously had epilepsy while 38% had not. The main underlying causes were noncompliance to treatment in the first group (n=56; 72%) and cerebrovascular disease (n=36; 75%) in the second group.  Overall mortality rate was 11.2% , which correlated with acute symptomatic etiology and patients of older age (mean: 73 years).

Conclusion: Epileptic patients are at greater risk to develop SE. However, in patients with no prior history of epilepsy and acute neurological problems SE may also occur. Cerebrovascular disease was the most common cause of SE in those with the initial seizure. Noncompliance to treatment was the major cause in patients with preexisting epilepsy.

Key words: epilepsy, status, etiology, clinical presentation, outcome


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Reference
1. Delanty N, French JA, Labar DR et al. Status epilepticus arising de novo in hospitalized patients: an analysis of 41 patients. Seizure 2001; 10(2):116-9. https://doi.org/10.1016/S1059-1311(00)90482-5  https://doi.org/10.1053/seiz.2000.0482  PMid:11407954
2. Di Bonaventura C, Mari F, Vanacore n et al. Status epilepticus in epileptic patients. Related syndromes, precipitating factors, treatment and outcome in a video-EEG population based study. Seizure 2008; 17(6):535-48. https://doi.org/10.1016/j.seizure.2008.02.002  PMid:18400524
3. Waterhouse JE, De Lorenzo JR. Status epilepticus in older patients. Drugs Aging 2001; 18(2):133-142. https://doi.org/10.2165/00002512-200118020-00006
4. Chin RF, Neville BG, Scott RC. A systematic review of the epidemiology of status epilepticus. Eur J Neurol 2004; 11(12):800-10. https://doi.org/10.1111/j.1468-1331.2004.00943.x  PMid:15667410
5. Marik EP, Varon J. The management of status epilepticus. CHEST 2004; 126:582-591. https://doi.org/10.1378/chest.126.2.582  PMid:15302747
6. Wu YW, Shek DW, Garcia PA et al. Incidence and mortality of generalized convulsive status epilepticus in California. Neurology 2002; 58(7):1070-6. https://doi.org/10.1212/WNL.58.7.1070
7. Hui AC, Joynt GM, Li H, Wong KS. Status epilepticus: aetiology, outcome and predictors of death and morbidity. Seizure 2003; 12(7):478-82. https://doi.org/10.1016/S1059-1311(03)00024-4
8. Govoni V, Fallica E, Monetti VC et al. Incidence of status epilepticus in southern Europe: a population study in the health district of Ferrara, Italy. Eur Neurol 2008; 59(3-4):120-6. https://doi.org/10.1159/000111873  PMid:18057897
9. Knake S, Rosenow F, Vescovi M et al. Incidence of status epilepticus in adults in Germanu: a prospective, population based study. Epilepsia 2001; 42(6):714-8. https://doi.org/10.1046/j.1528-1157.2001.01101.x  PMid:11422324
10. Garzon E, Fernandes RM, Sakamoto AC. Analysis of clinical characteristics and risk factors for mortality in human status epilepticus. Seizure 2003; 12(6):337-45. https://doi.org/10.1016/S1059-1311(02)00324-2
11. Vignatelli L, Rinaldi R, Galeotti M et al. Epidemiology of status epilepticus in a rural area of northern Italy: a 2-year populatin based study. Eur J Neurol 2005; 12(11):897-902. https://doi.org/10.1111/j.1468-1331.2005.01073.x  PMid:16241980
12. Božić K, Žikić M, Mišić-Pavkov G. et al. Occurrence, causes and clinical characteristics of status epilepticus in adults. Med Pregl 1998; 51(5-6):254-8. PMid:9720354
13. Afsar N, Kaya D, Atkan s et al. Stroke and ststus epilepticus: stroke type, type of status epilepticus, and prognosis. Seizure 2003; 12(1):23-7. https://doi.org/10.1016/S1059131102001437  PMid:12495645
14. Darcel G, Verstichel P, Herbaund S et al. Status epilepticus in elderly patients. A retrospective study of 63 in-patients. Rev Neurol 2008, 164(11):935-42. https://doi.org/10.1016/j.neurol.2008.04.007  PMid:18808782
15. Amare A, Zenebe G, hammack J, Davey G. Status epilepticus: clinical presentatio, cause, outcome and predictors of death in 119 Ethiopian patients. Epilepsia 2008; 4984):600-7.
16. Rosenow F, Hamer HM, Knake S. The epidemiology of convulsive and neconvulsive status epilepticus. Epilepsia 2007; 48(suppl 8):82-4. https://doi.org/10.1111/j.1528-1167.2007.01359.x  PMid:18330009
17. Rossetti AO, Hurwitz S, Logroscino G, Bromfield EB. Prognosis of status epilepticus: role of aetiology, age and consciousness inpairment at presentation. J neurol neurosur Psychiatry 2006; 77(5):611-5. https://doi.org/10.1136/jnnp.2005.080887  PMid:16614020 PMCid:PMC2117456
18. Rodriguez U, Franco ME, Delgado Lf. Epileptic status in chronic renal failure. Med Clin 2004; 123(10):399.
19. Tanaka H, Ueda H, Kida Y et al. Hepatic encephalopathy with status epilepticus: a case report. World J Gastroenterol 2006; 12(11):1793-4. https://doi.org/10.3748/wjg.v12.i11.1793  PMid:16586556 PMCid:PMC4124362


Contact address:
Duško Račić
K Department of Neurology
UCC, the Republic of Srpska
Street address: NN 12 beba
78000 Banja Luka,
Republic of Srpska
Bosnia and Herzegovina
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
phone number: +387-65-511-510

Submitted: March 5th, 2018
Accepted: March 18th, 2018