ISSN 2490-3329 (Print)
ISSN 2303-7954 (Online)

Volume 49, Issue 1, Article 2

(Scr Med 2018:49:13-17)

Effects of Transcranial Galvanic Stimulation on Post Stroke Depression

Draško Prtina¹

¹Institute for Physical Medicine and Rehabilitation ”Dr Miroslav Zotović” Banja Luka, Republic of Srpska


doi: 10.18575/
UDC: 616.831-005.1
COBISS.RS-ID: 7316504


Introduction:Transcranial galvanic stimulation (TGS), a non-invasive method in modulation of cortical excitability, shows potentially positive effects on post stroke depression (PSD)

Aim of the Study: The aim of this study was to estimate the effects of transcranial galvanic stimulation on post-stroke depression in patients after acute stroke.

Patients and Methods: The study group (N=11) received TGS and conventional physical and occupational therapy. All patients were stimulated with transcranial galvanic stimulation for 20 minutes with 1mA current intensity, once a day fortwo weeks (five days a week).The Beck Depression Inventory was applied to score the depression levels in patients before and after the intervention.

Results:Application of TGS therapy, along with a conventional rehabilitation treatment entailed a statistically significant decrease in the level of depression in our group of patients. There was no statistically significant difference regarding depression in relation to genders, localization and type of stroke.

Conclusion:The study has confirmed that the application oftranscranial galvanic stimulation during stroke rehabilitation improves the depression symptoms in patients.

Key words: Transcranial Galvanic Stimulation, Post Stroke Depression

Pdf version of article

1. Albert SJ, Kesselring J, Neurorehabilitation of stroke. J Neurol. 2012 May; 259(5):817-32.  PMid:21964750
2. Hendricks HT, van Limbeek J, Geurts AC, Zwarts MJ, Motor recovery after stroke: a systematic review of the literature. Arch Phys Med Rehabil. 2002 Nov;83(11):1629-37.  PMid:12422337   
3. Nowak DA, Grefkes C, Ameli M, Fink GR, Interhemispheric competition after stroke: brain stimulation to enhance recovery of function of the affected hand. Neurorehabil Neural Repair. 2009 Sep;23(7):641-56.  PMid:19531606   
4. Hesse S, Waldner A, Mehrholz J, Tomelleri C, Pohl M, Werner C, Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: an exploratory, randomized multicenter trial. Neurorehabil Neural Repair. 2011 Nov-Dec;25(9):838-46.  PMid:21825004   
5. Lindenberg R, Nair D, Zhu LL, Renga V, Schlaug G, Noninvasive motor cortex stimulation after stroke: the effect of number of sessions on outcome. Stroke 2011;42(3):e72.   
6. Bindman LJ, Lippold CJ, Redfeam JFT, The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J Physiol. 1964 Aug; 172(3): 369–382.  PMid:14199369 PMCid:PMC1368854   
7. Nitsche MA, Liebetanz D, Antal A, Lang N, Tergau F, Paulus W, Modulation of cortical excitability by weak direct current stimulation-technical, safety and functional aspects. Suppl Clin Neurophysiol. 2003;56:255-76.
8. Reis J, Schambra HM, Cohen LG, Buch ER, Fritsch B, Zarahn E, Celnik PA, Krakauer JW, Noninvasive cortical stimulation enhances motor skill acquisition over multiple days through an effect on consolidation. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1590-5.  PMid:19164589 PMCid:PMC2635787   
9. Pohjasvaara T, Vataja R, Leppävuori A, et al.: Depression is an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol, 2001, 8: 315–319.  PMid:11422427   
10. Robinson RG. Poststroke depression: prevalence, diagnosis, treatment, and disease progression. Biol Psychiatry. 2003;54:376–87.
11. Valiengo LC, Goulart AC, de Oliveira JF, Transcranial direct current stimulation for the treatment of post-stroke depression: results from a randomised, sham-controlled, double-blinded trial. J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):170-175  PMid:27815324   

Contact address:
Draško Prtina
Street address: Aleja Svetog Save 49
78000 Banja Luka,
Republic of Srpska
Bosnia and Herzegovina
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
phone number: +387-65-660-360
Submitted: March 3rd, 2018
Accepted: March 27th, 2018